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A Beginner’s Guide to Medicare Drug Price Negotiation Under the Inflation Reduction Act

Gain a clear understanding of how the Inflation Reduction Act (IRA) is reshaping Medicare drug pricing and the broader pharmaceutical policy landscape in the United States. This white paper explores the fundamentals of the Medicare Drug Price Negotiation Program, including how drugs are selected, how negotiated prices are determined, and the implications for manufacturers, investors, payers, providers, and patients. Covering the first negotiation cycles, recent policy developments, and emerging future considerations, it provides an accessible overview of one of the most significant healthcare policy reforms in decades. Download now to stay informed on the evolving future of Medicare drug pricing and pharmaceutical policy.

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Charting the Landscape of Real-World Data in the United States

Explore how real-world data (RWD) is transforming healthcare and life sciences in Charting the Landscape of Real-World Data in the U.S. by Polygon Health Analytics. This white paper maps key data sources, highlights practical applications across sectors, and addresses challenges in access, quality, and analytics. Whether you’re a researcher, clinician, policymaker, or data strategist, this guide offers actionable insights and best practices for leveraging RWD to drive innovation, equity, and evidence-based decisions. Download now to stay ahead in the evolving data-driven healthcare ecosystem.

Blog & News

FDA Approval Is Not the Finish Line: The Long Journey from Innovation to Patient Access
FDA Approval Is Not the Finish Line: The Long Journey from Innovation to Patient Access
Oct 28, 2026
A drug can be scientifically validated, clinically effective, and officially approved by the FDA. Yet patients may still be unable to get it. That sounds counterintuitive,...
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Biology Has No Compiler: Why AI Hasn't Bent Eroom's Law (Yet)
Biology Has No Compiler: Why AI Hasn't Bent Eroom's Law (Yet)
Oct 21, 2026
AI-driven drug discovery is experiencing a fascinating paradox. On one hand, Isomorphic Labs, the AI drug discovery company spun out of Alphabet and led by Nobel...
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AI Credibility Is an Evidence Problem. FDA Just Reorganized Around It.
AI Credibility Is an Evidence Problem. FDA Just Reorganized Around It.
Oct 05, 2026
On October 1, FDA's Center for Drug Evaluation and Research (CDER) began operating a new Office of Innovation and Clinical Trial Modernization (OICTM) within...
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What Igalmi Teaches Us About FDA Approval and Commercial Return
What Igalmi Teaches Us About FDA Approval and Commercial Return
Sep 15, 2026
FDA approval is a scientific and regulatory achievement. It does not guarantee that a medicine will recover its development costs, sustain commercialization, or fund its next...
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What Robotics Can Teach Us About the Data AI Needs for Life Sciences
What Robotics Can Teach Us About the Data AI Needs for Life Sciences
Sep 11, 2026
Large language models have benefited from enormous collections of existing internet content. Robotics faces a different challenge: much of the information a machine needs to learn...
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Before You Buy Real-World Data: Five Questions Your Study Team Should Answer
Before You Buy Real-World Data: Five Questions Your Study Team Should Answer
Sep 06, 2026
Real-world data licensing is expensive: hundreds of thousands to millions of dollars a year. A data provider's presentation can make a dataset look ideal:...
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Polygon Health Analytics Publishes First Peer-Reviewed Study from LaunchPad Program
Polygon Health Analytics Publishes First Peer-Reviewed Study from LaunchPad Program
Jul 22, 2026
Philadelphia, PA — July 22, 2026 — Polygon Health Analytics announced the publication of a new peer-reviewed study in Lupus Science & Medicine that demonstrates how artificial intelligence...
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MFN Drug Pricing Explained: 10 Questions About Cost, Access, and Market Impact
MFN Drug Pricing Explained: 10 Questions About Cost, Access, and Market Impact
Jul 21, 2026
Prescription drug pricing is again at the center of U.S. healthcare policy. The latest focus is Most-Favored-Nation (MFN) pricing, an approach that uses prices paid...
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The Matching Problem: Why Finding the Right One Is So Hard, and Why AI Can’t Fix It
The Matching Problem: Why Finding the Right One Is So Hard, and Why AI Can’t Fix It
Jul 11, 2026
A few weeks ago I listened to a group of friends vent about dating apps: the endless swiping, the false starts, the fatigue. I could relate....
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The Million-Dollar Slide: A Sharper Way to Think About Real-World Data Quality
The Million-Dollar Slide: A Sharper Way to Think About Real-World Data Quality
Jul 05, 2026
by Lixia Yao, PhD At the DIA 2026 Annual Meeting, I sat through hundreds of slides. Most conveyed useful information. A few introduced new ideas. But...
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Trust the Experts—But Which Experts?
Trust the Experts—But Which Experts?
Jun 12, 2026
“Leave professional matters to the professionals.” It’s one of those pieces of advice that feels self-evidently correct—and it is. We rely on physicians for...
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The Adult in the Room: What Gwynne Shotwell Teaches Us About Women's Leadership
The Adult in the Room: What Gwynne Shotwell Teaches Us About Women's Leadership
Jun 10, 2026
Elon Musk once said that without Gwynne, SpaceX would have gone under long ago. Most people have never heard her name. That gap — between how essential...
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