Founded in January 2023 by the highly cited data scientist in healthcare, Dr. Lixia Yao, Polygon Health Analytics LLC may be a young company, but our team is composed of experts with decades of experience and a deep understanding of the US healthcare ecosystem. 

We have a proven track record in bridging the gap between healthcare delivery systems, biopharmaceutical companies, and technology firms. We provide Real-World Data (RWD) and artificial intelligence solutions to address the unique needs of clients in drug discovery, clinical development, health economics and outcome research (HEOR), and product commercialization. 

Our commitment to improving global health outcomes while delivering substantial business value sets us apart from traditional vendors. We offer exceptional, efficient, and cost-effective RWD solutions underpinned by: 

         In-depth Understanding: We have a comprehensive understanding of the intricacies of the healthcare ecosystem, market access, and reimbursement in the U.S. 

         Extensive Network: Our vast network includes key opinion leaders, esteemed clinics, and reputable hospitals across the United States. 

         Demonstrated Scientific Excellence: Our track record of scientific publications showcases our successful use of real-world data to guide crucial decisions in the healthcare and pharmaceutical sectors.

Competitive Advantages



Our relentless drive to improve global health and create business benefits fuels our every endeavor. We are committed to making a difference in the world of healthcare.



Our deep understanding of the healthcare ecosystem, including health delivery systems, biopharma, and tech companies, allows us to provide tailored solutions that address the unique challenges of each sector.



Our strong connections with Key Opinion Leaders and health delivery systems in the US and around the world enable us to stay at the forefront of healthcare trends and innovations.

Scientific Rigor

Our established track record of science and innovation is a testament to the expertise and dedication of our team. We leverage this scientific rigor to deliver high-quality, evidence-based solutions.


Our ability to communicate the impact of emerging technologies to a wide range of audiences, from fresh graduates to C-suite executives, ensures that our clients are well-informed and equipped to make strategic decisions.

Leadership Team

Lixia Yao

Lixia Yao

Founder & CEO

Dr. Lixia Yao is the founder and CEO of Polygon Health Analytics LLC, which specializes in developing high-quality real-world data (RWD) and real-world evidence (RWE) in disease areas with pressing unmet medical needs. With a PhD in Biomedical Informatics from Columbia University, Dr. Yao previously worked as the director of Real-world Data Analytics & Innovation at Merck and an Associate Professor in Biomedical Informatics at Mayo Clinic. She has cultivated a deep understanding of RWD and authored 60+ peer-reviewed articles on prestigious journals such as Nature Biotechnology, Genome Research, and Drug Discovery Today with a H-index of 20. Dr. Yao received the Career Development Award in Biomedical Informatics from the National Library of Medicine (2016-2019). She is also a Fellow of the American Medical Informatics Association (FAMIA) and served as the Chair of the AMIA KDDM working group (2020-2022). Currently, she holds the additional roles of Member Engagement Co-Chair for the Oncology Special Interest Group at the Professional Society for Health Economics and Outcomes Research (ISPOR), Director of Business Insights & Analytics at SAPA-GP, and Adjunct Associate Professor in the Department of Health Services Administration and Policy at Temple University.

Leonard Refford

Leonard Refford


Mr. Refford serves as the Chief Financial Officer by bringing a wealth of experience and a proven track record of success in the financial sector. A Certified Public Accountant, he has amassed 20 years of diverse accounting experiences for small and growth business, demonstrating a strong ability to work under pressure and complete all assigned tasks to accomplish organizational goals. Known for his efficiency, attention to detail, and highly organized approach, Mr. Refford has a keen focus on problem-solving. His strong analytical and technical skills have been instrumental in his role. At Polygon Health Analytics LLC, Mr. Refford is responsible for overseeing professional finance, accounting, payroll, and tax operations, ensuring the financial health and sustainability of the organization.

Yupeng Li

Yupeng Li


Dr. Li is a seasoned expert in the field of pharmaceutical data science with a rich, 8-year background spanning early-stage drug discovery, clinical trials, and real-world evidence. His career has been marked by pioneering innovative statistical and machine learning algorithms, designed to uncover insights from complex biological and healthcare datasets, leading strategic initiatives in AI and data science applications within healthcare, and contributing to advances in drug discovery and development using data and digital technologies.


Madhuri Maddipatla

Director of Business Development

Madhuri Maddipatla, former McKinsey consultant with 15+ years of analytics consulting expertise, is the Director of Business Development at Polygon Health Analytics. Leveraging her strategic prowess, she drives business growth and cultivates impactful client relationships. Madhuri's commitment to innovation aligns with Polygon's vision, positioning the company as a leader in applying Real-World Data and AI technologies for healthcare advancement.

Strategic Partners

University of Michigan

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