Case #3: Systematic Literature Review on Real-World Effectiveness and Safety of Factor Xa Inhibitors
Various factor Xa inhibitors are widely prescribed for atrial fibrillation.
A manufacturer of a factor Xa inhibitor sought our expertise for a systematic literature review to understand
the real-world effectiveness and safety of different factor Xa inhibitors used in the European Union.
Challenge
Biopharmaceutical companies needed to understand the comparative effectiveness
and safety of different factor Xa inhibitors in routine clinical settings to
inform their strategic decisions.
Solution
Polygon Health Analytics conducted a systematic literature review
of independent research from 2022 to 2024, focusing on real-world data
and excluding studies sponsored by pharmaceutical companies.
The review assessed outcomes such as stroke, systemic embolism, major bleeding, and mortality.
Outcomes
We found that all factor Xa inhibitors demonstrated robust efficacy and
safety profiles. The systematic literature review was accepted for presentation at the
ISPOR 2025 annual conference.
"I am very happy with the Polygon Health Analytics team's performance.
They listen to clients' needs and deliver promptly and with high quality.
I will definitely work with them more in the future."
Lisa
Director of Global HEOR
